.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DE02_Cefpirome.Cefpirome

Information

Cefpirome is a fourth-generation cephalosporin antibiotic that is used to treat severe bacterial infections including those caused by Gram-negative and some Gram-positive organisms. It is administered intravenously, primarily in hospital settings for complicated infections. Although widely used in some regions, in others its clinical use is limited or discontinued.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after single intravenous infusion.

References

1. Kang, S, et al., & Chang, MJ (2020). Dose Optimization of Cefpirome Based on Population Pharmacokinetics and Target Attainment during Extracorporeal Membrane Oxygenation. Antimicrobial agents and chemotherapy 64(5) –. DOI:10.1128/AAC.00249-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32122899

2. Roos, JF, et al., & Kirkpatrick, CMJ (2007). Population pharmacokinetics and pharmacodynamics of cefpirome in critically ill patients against Gram-negative bacteria. Intensive care medicine 33(5) 781–788. DOI:10.1007/s00134-007-0573-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17342515

3. Bulitta, JB, et al., & Sörgel, F (2011). Comparable population pharmacokinetics and pharmacodynamic breakpoints of cefpirome in cystic fibrosis patients and healthy volunteers. Antimicrobial agents and chemotherapy 55(6) 2927–2936. DOI:10.1128/AAC.01484-10 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21402834

Revisions

• 06/2025 initial generated model