.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DF01_Aztreonam.Aztreonam

Information

Aztreonam is a monobactam antibiotic used primarily to treat infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. It is administered mainly by intravenous or intramuscular injection and is approved for use in various countries today, particularly for patients with beta-lactam allergies.

Pharmacokinetics

Pharmacokinetic parameters reported for adult healthy volunteers after single dose intravenous administration.

References

1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

2. Xu, H, et al., & Al-Huniti, N (2017). Evaluation of Aztreonam Dosing Regimens in Patients With Normal and Impaired Renal Function: A Population Pharmacokinetic Modeling and Monte Carlo Simulation Analysis. Journal of clinical pharmacology 57(3) 336–344. DOI:10.1002/jcph.810 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27530649

3. Stutman, HR (1989). Aztreonam: clinical pharmacology. The Pediatric infectious disease journal 8(9 Suppl) S104–S132. PUBMED:https://pubmed.ncbi.nlm.nih.gov/2682507

Revisions

• 06/2025 initial generated model