.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DH03_Ertapenem.Ertapenem

Information

Ertapenem is a broad-spectrum carbapenem antibiotic used to treat a variety of infections caused by susceptible Gram-positive and Gram-negative bacteria, including intra-abdominal infections, community-acquired pneumonia, skin and soft tissue infections, and urinary tract infections. It is approved and currently used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after a single intravenous dose.

References

1. Goutelle, S, et al., & Ferry, T (2018). Population pharmacokinetics and probability of target attainment of ertapenem administered by subcutaneous or intravenous route in patients with bone and joint infection. The Journal of antimicrobial chemotherapy 73(4) 987–994. DOI:10.1093/jac/dkx477 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29244077

2. Boulamery, A, et al., & Simon, N (2014). Population pharmacokinetics of ertapenem in juvenile and old rats. Fundamental & clinical pharmacology 28(2) 144–150. DOI:10.1111/fcp.12017 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23647486

3. Zhou, J, et al., & Tam, VH (2014). Pharmacokinetics of ertapenem in outpatients with complicated urinary tract infections. The Journal of antimicrobial chemotherapy 69(9) 2517–2521. DOI:10.1093/jac/dku143 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24797063

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)