.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DH51_ImipenemAndCilastatin.ImipenemAndCilastatin .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DH51_ImipenemAndCilastatin.ImipenemAndCilastatin| name: | ImipenemAndCilastatin |
| ATC code: | J01DH51 | route: | intravenous |
| n-compartments | 2 |
Imipenem and cilastatin is a combination antibiotic approved for treatment of serious bacterial infections, particularly hospital-acquired or complicated infections caused by susceptible organisms. Imipenem is a broad-spectrum beta-lactam carbapenem antibiotic, while cilastatin is a dehydropeptidase inhibitor added to prevent the renal breakdown of imipenem and prolong its antibacterial activity.
Pharmacokinetic parameters reported for healthy adult subjects after intravenous administration.
Sakka, SG, et al., & Sörgel, F (2007). Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial. Antimicrobial agents and chemotherapy 51(9) 3304–3310. DOI:10.1128/AAC.01318-06 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17620371