.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01E_SulfonamidesAndTrimethoprim.J01EA01_Trimethoprim.Trimethoprim

Information

Trimethoprim is an antibiotic that inhibits bacterial dihydrofolate reductase, interfering with folic acid synthesis required for bacterial DNA replication. It is commonly used, often in combination with sulfamethoxazole, for the treatment of urinary tract infections and a variety of other bacterial infections. Trimethoprim is a widely approved and routinely prescribed antimicrobial agent.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers following oral administration.

References

1. Wu, YSS, et al., & Gonzalez, D (2021). External Evaluation of Two Pediatric Population Pharmacokinetics Models of Oral Trimethoprim and Sulfamethoxazole. Antimicrobial agents and chemotherapy 65(7) e0214920–None. DOI:10.1128/AAC.02149-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33903114

2. Autmizguine, J, et al., & Gonzalez, D (2018). Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children. Antimicrobial agents and chemotherapy 62(1) –. DOI:10.1128/AAC.01813-17 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29084742

3. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

Revisions

• 06/2025 initial generated model