.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01E_SulfonamidesAndTrimethoprim.J01EC01_Sulfamethoxazole.Sulfamethoxazole

Information

name:Sulfamethoxazole
ATC code:J01EC01
route:oral
n-compartments1

Sulfamethoxazole is an antibiotic of the sulfonamide class, commonly used in combination with trimethoprim to treat a wide variety of bacterial infections, including urinary tract infections, bronchitis, and certain types of diarrhea. It acts by inhibiting the bacterial synthesis of dihydrofolic acid. Sulfamethoxazole is generally used in clinical practice today as part of the combination drug cotrimoxazole.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after oral administration.

References

  1. Wu, YSS, et al., & Gonzalez, D (2021). External Evaluation of Two Pediatric Population Pharmacokinetics Models of Oral Trimethoprim and Sulfamethoxazole. Antimicrobial agents and chemotherapy 65(7) e0214920–None. DOI:10.1128/AAC.02149-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33903114

  2. Autmizguine, J, et al., & Gonzalez, D (2018). Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children. Antimicrobial agents and chemotherapy 62(1) –. DOI:10.1128/AAC.01813-17 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29084742

  3. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

Revisions


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