name: | SulfamethoxazoleAndTrimethoprimCombination |
ATC code: | J01EC20 | route: | oral |
n-compartments | 1 |
A combination antibacterial drug consisting of sulfamethoxazole, a sulfonamide, and trimethoprim, a dihydrofolate reductase inhibitor. This combination is used to treat urinary tract infections, respiratory tract infections and other bacterial infections, and is widely approved for clinical use.
Pharmacokinetic parameters in healthy adult volunteers after a single oral dose of 800 mg sulfamethoxazole combined with 160 mg trimethoprim (co-trimoxazole).
Wu, YSS, et al., & Gonzalez, D (2021). External Evaluation of Two Pediatric Population Pharmacokinetics Models of Oral Trimethoprim and Sulfamethoxazole. Antimicrobial agents and chemotherapy 65(7) e0214920–None. DOI:10.1128/AAC.02149-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33903114
Autmizguine, J, et al., & Gonzalez, D (2018). Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children. Antimicrobial agents and chemotherapy 62(1) –. DOI:10.1128/AAC.01813-17 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29084742
Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866