.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01G_AminoglycosideAntibacterials.J01GA01_Streptomycin.Streptomycin

Information

name:Streptomycin
ATC code:J01GA01
route:intravenous
n-compartments2

Streptomycin is an aminoglycoside antibiotic discovered in 1943, primarily used to treat tuberculosis and various infections caused by Gram-negative bacteria. It was historically important for its effectiveness against Mycobacterium tuberculosis but is now less frequently used due to resistance and toxicity concerns. It remains on the WHO List of Essential Medicines and is approved for limited use today.

Pharmacokinetics

Pharmacokinetic parameters in adult healthy volunteers after single intravenous infusion of streptomycin; both males and females included.

References

  1. Zhu, M, et al., & Peloquin, CA (2001). Population pharmacokinetics of intravenous and intramuscular streptomycin in patients with tuberculosis. Pharmacotherapy 21(9) 1037–1045. DOI:10.1592/phco.21.13.1037.34625 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11560193

  2. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

Revisions


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