.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01G_AminoglycosideAntibacterials.J01GB03_Gentamicin.Gentamicin .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01G_AminoglycosideAntibacterials.J01GB03_Gentamicin.Gentamicin| name: | Gentamicin | |
| ATC code: | J01GB03 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 80 | mg |
| volume of distribution: | 0.25 | L |
| clearance: | 4.6 | L/h |
| other parameters in model implementation | ||
Gentamicin is an aminoglycoside antibiotic primarily used for the treatment of serious infections caused by susceptible strains of Gram-negative bacteria. It is commonly used for sepsis, respiratory tract infections, urinary tract infections, and intra-abdominal infections. Gentamicin is approved and widely used in clinical settings, particularly in hospitals.
Pharmacokinetic parameters reported for adult patients with normal renal function (mean age ~40 years, both sexes).
Medellín-Garibay, SE, et al., & Barcia, E (2015). Population pharmacokinetics of gentamicin and dosing optimization for infants. Antimicrobial agents and chemotherapy 59(1) 482–489. DOI:10.1128/AAC.03464-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25385111
Boisson, M, et al., & Grégoire, N (2018). Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. The Journal of antimicrobial chemotherapy 73(10) 2830–2837. DOI:10.1093/jac/dky239 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947799
Lares-Asseff, I, et al., & Lugo Goytia, G (2016). Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition. The Pediatric infectious disease journal 35(8) 872–878. DOI:10.1097/INF.0000000000001204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27420805