.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01G_AminoglycosideAntibacterials.J01GB03_Gentamicin.Gentamicin

Information

Gentamicin is an aminoglycoside antibiotic primarily used for the treatment of serious infections caused by susceptible strains of Gram-negative bacteria. It is commonly used for sepsis, respiratory tract infections, urinary tract infections, and intra-abdominal infections. Gentamicin is approved and widely used in clinical settings, particularly in hospitals.

Pharmacokinetics

Pharmacokinetic parameters reported for adult patients with normal renal function (mean age ~40 years, both sexes).

References

1. Medellín-Garibay, SE, et al., & Barcia, E (2015). Population pharmacokinetics of gentamicin and dosing optimization for infants. Antimicrobial agents and chemotherapy 59(1) 482–489. DOI:10.1128/AAC.03464-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25385111

2. Boisson, M, et al., & Grégoire, N (2018). Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. The Journal of antimicrobial chemotherapy 73(10) 2830–2837. DOI:10.1093/jac/dky239 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947799

3. Lares-Asseff, I, et al., & Lugo Goytia, G (2016). Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition. The Pediatric infectious disease journal 35(8) 872–878. DOI:10.1097/INF.0000000000001204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27420805

Revisions

• 06/2025 initial generated model