.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01G_AminoglycosideAntibacterials.J01GB11_Isepamicin.Isepamicin

Information

Isepamicin is an aminoglycoside antibiotic, structurally related to gentamicin and amikacin, primarily used for the treatment of severe infections caused by Gram-negative bacteria. It was mainly developed and used in some Asian countries, but is not globally approved or widely available today.

Pharmacokinetics

Pharmacokinetic parameters in adult patients with normal renal function.

References

1. Barr, WH, et al., & Affrime, MB (1995). Pharmacokinetics of isepamicin. Journal of chemotherapy (Florence, Italy) 7 Suppl 2 53–61. PUBMED:https://pubmed.ncbi.nlm.nih.gov/8622111

2. Tod, M, et al., & Petitjean, O (1996). Population pharmacokinetic study of isepamicin with intensive care unit patients. Antimicrobial agents and chemotherapy 40(4) 983–987. DOI:10.1128/AAC.40.4.983 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8849264

3. Yombi, JC, et al., & Vandercam, B (2005). Key pharmacokinetic parameters of isepamicin in febrile neutropenic cancer patients and in women with acute pelvic inflammatory disease. Journal of chemotherapy (Florence, Italy) 17(5) 521–526. DOI:10.1179/joc.2005.17.5.521 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16323441

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)