.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01R_CombinationsOfAntibacterials.J01RA06_CefepimeAndAmikacin.CefepimeAndAmikacin

Information

Cefepime and amikacin is a combination of two antibiotics (cefepime: a fourth-generation cephalosporin and amikacin: an aminoglycoside) used to treat severe bacterial infections, especially in hospital settings for gram-negative bacteria including Pseudomonas species. This combination is commonly employed for empiric or targeted therapy in serious infections, especially in immunocompromised patients. Both drugs are approved and commonly used individually.

Pharmacokinetics

Estimated pharmacokinetic parameters for typical adult patients with normal renal function. Actual published PK data for the combined formulation with ATC code J01RA06 (cefepime and amikacin) is not available; parameters are estimated based on individual component data.

References

1. Bateman, RM, et al., & Prandi, E (2016). 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Critical care (London, England) 20(Suppl 2) 94–None. DOI:10.1186/s13054-016-1208-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27885969

Revisions

• 06/2025 initial generated model