.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01X_OtherAntibacterials.J01XD01_Metronidazole.Metronidazole_1

Information

Metronidazole is a nitroimidazole antimicrobial agent used primarily to treat infections caused by anaerobic bacteria and certain parasites. It is approved for use in bacterial vaginosis, trichomoniasis, giardiasis, amebiasis, and various anaerobic infections. Metronidazole is widely used in clinical practice, both in hospital and outpatient settings.

Pharmacokinetics

Pharmacokinetic parameters following single intravenous infusion in healthy adults.

References

1. Suyagh, M, et al., & McElnay, JC (2011). Metronidazole population pharmacokinetics in preterm neonates using dried blood-spot sampling. Pediatrics 127(2) e367–e374. DOI:10.1542/peds.2010-0807 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21220396

2. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

3. Arnold, DT, et al., & MacGowan, A (2024). Antibiotic pharmacokinetics in infected pleural effusions. Thorax 79(9) 883–885. DOI:10.1136/thorax-2023-220402 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38964858

Revisions

• 06/2025 initial generated model