.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01X_OtherAntibacterials.J01XE01_Nitrofurantoin.Nitrofurantoin .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01X_OtherAntibacterials.J01XE01_Nitrofurantoin.Nitrofurantoin| name: | Nitrofurantoin |
| ATC code: | J01XE01 | route: | oral |
| n-compartments | 1 |
Nitrofurantoin is an antibacterial agent used primarily for the treatment and prophylaxis of urinary tract infections (UTIs). It is effective mainly against Escherichia coli and some other Gram-negative and Gram-positive bacteria. It is approved and widely used today for uncomplicated UTIs, particularly in women.
Pharmacokinetic parameters reported for healthy adult volunteers (both sexes) after oral administration of nitrofurantoin macrocrystals.
Adkison, KK, et al., & Lee, EJ (2008). The ABCG2 C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects. British journal of clinical pharmacology 66(2) 233–239. DOI:10.1111/j.1365-2125.2008.03184.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/18429968
Wijma, RA, et al., & Muller, AE (2018). Review of the pharmacokinetic properties of nitrofurantoin and nitroxoline. The Journal of antimicrobial chemotherapy 73(11) 2916–2926. DOI:10.1093/jac/dky255 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30184207
Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982