.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J02A_AntimycoticsForSystemicUse.J02AC03_Voriconazole.Voriconazole

Information

name:Voriconazole
ATC code:J02AC03
route:oral
n-compartments2

Voriconazole is a triazole antifungal medication approved for the treatment of invasive aspergillosis and serious infections caused by other yeasts and fungi, such as Candida species. It is used in immunocompromised patients, including those with hematopoietic stem cell transplants or advanced HIV infection, and remains widely approved and in clinical use today.

Pharmacokinetics

Pharmacokinetics reported in healthy adult volunteers, both male and female, after a single oral dose under fasting conditions.

References

  1. Chen, N, et al., & Lu, X (2023). Population Pharmacokinetics of Isavuconazole in Adult: A Systematic Review. Infection and drug resistance 16 7559–7568. DOI:10.2147/IDR.S434622 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38089964

  2. Hope, WW (2012). Population pharmacokinetics of voriconazole in adults. Antimicrobial agents and chemotherapy 56(1) 526–531. DOI:10.1128/AAC.00702-11 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22064545

  3. Tang, D, et al., & Xiang, DX (2021). Population pharmacokinetics, safety and dosing optimization of voriconazole in patients with liver dysfunction: A prospective observational study. British journal of clinical pharmacology 87(4) 1890–1902. DOI:10.1111/bcp.14578 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33010043

Revisions


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