name: | Voriconazole_1 | |
ATC code: | J02AC03_1 | route: | intravenous |
compartments: | 2 | |
dosage: | 6 | mg |
volume of distribution: | 4.5 | L |
clearance: | 5.6 | L/h |
other parameters in model implementation |
Voriconazole is a triazole antifungal medication approved for the treatment of invasive aspergillosis and other serious fungal infections.
Pharmacokinetics reported in adults after intravenous administration.
Wang, J, et al., & Ge, W (2024). Population Pharmacokinetics of Voriconazole and Dose Optimization in Elderly Chinese Patients. Journal of clinical pharmacology 64(2) 253–263. DOI:10.1002/jcph.2357 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37766506
Hope, WW (2012). Population pharmacokinetics of voriconazole in adults. Antimicrobial agents and chemotherapy 56(1) 526–531. DOI:10.1128/AAC.00702-11 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22064545
Tang, D, et al., & Xiang, DX (2021). Population pharmacokinetics, safety and dosing optimization of voriconazole in patients with liver dysfunction: A prospective observational study. British journal of clinical pharmacology 87(4) 1890–1902. DOI:10.1111/bcp.14578 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33010043