.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J02A_AntimycoticsForSystemicUse.J02AC04_Posaconazole.Posaconazole_1

Information

name:Posaconazole_1
ATC code:J02AC04_1
route:intravenous
n-compartments2

Posaconazole is a triazole antifungal agent approved for the prevention and treatment of invasive fungal infections caused by Aspergillus and Candida species in immunocompromised patients. It is used both for prophylaxis in patients at high risk for fungal infections and for treatment of ongoing invasive infections. Approved by FDA and widely used in clinical practice.

Pharmacokinetics

Healthy adult volunteers, single-dose pharmacokinetics following 200 mg intravenous infusion over 30 minutes.

References

  1. Chen, L, et al., & Brüggemann, RJM (2020). Pharmacokinetics and Pharmacodynamics of Posaconazole. Drugs 80(7) 671–695. DOI:10.1007/s40265-020-01306-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/32323222

  2. Sime, FB, et al., & Roberts, JA (2019). Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients. Critical care (London, England) 23(1) 205–None. DOI:10.1186/s13054-019-2483-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31171022

  3. Ding, Q, et al., & Pei, Q (2022). A Review of Population Pharmacokinetic Models of Posaconazole. Drug design, development and therapy 16 3691–3709. DOI:10.2147/DDDT.S384637 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36277600

Revisions


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