.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J02A_AntimycoticsForSystemicUse.J02AX04_Caspofungin.Caspofungin

Information

Caspofungin is an echinocandin antifungal agent approved for the treatment of invasive aspergillosis in patients who are refractory to or intolerant of other therapies, as well as for empirical therapy for presumed fungal infections in febrile neutropenic patients. It is also used against Candida infections, including candidemia and esophageal candidiasis.

Pharmacokinetics

Pharmacokinetic parameters reported for adult healthy volunteers and patients with invasive fungal infections. Intravenous infusion. Parameters represent typical administration of a 70 mg loading dose followed by 50 mg daily.

References

1. Borsuk-De Moor, A, et al., & Wiczling, P (2020). Nonstationary Pharmacokinetics of Caspofungin in ICU Patients. Antimicrobial agents and chemotherapy 64(9) –. DOI:10.1128/AAC.00345-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32601169

2. Li, CC, et al., & Stone, JA (2011). Population pharmacokinetics and pharmacodynamics of caspofungin in pediatric patients. Antimicrobial agents and chemotherapy 55(5) 2098–2105. DOI:10.1128/AAC.00905-10 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21300834

3. Leshinsky, J, et al., & Barrs, VR (2017). Pharmacokinetics of caspofungin acetate to guide optimal dosing in cats. PloS one 12(6) e0178783–None. DOI:10.1371/journal.pone.0178783 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28575121

Revisions

• 06/2025 initial generated model