.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J04A_DrugsForTreatmentOfTuberculosis.J04AA02_SodiumAminosalicylate.SodiumAminosalicylate .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J04A_DrugsForTreatmentOfTuberculosis.J04AA02_SodiumAminosalicylate.SodiumAminosalicylate| name: | SodiumAminosalicylate | |
| ATC code: | J04AA02 | route: | oral |
| compartments: | 1 | |
| dosage: | 4000 | mg |
| volume of distribution: | 15.6 | L |
| clearance: | 4.7 | L/h |
| other parameters in model implementation | ||
Sodium aminosalicylate (para-aminosalicylic acid, PAS) is an antibiotic primarily used for the treatment of tuberculosis. It acts as a bacteriostatic agent by inhibiting folic acid synthesis in Mycobacterium tuberculosis. Previously a first-line agent in tuberculosis therapy, it is now mainly used as a second-line drug, especially for multidrug-resistant tuberculosis, owing to the availability of more effective agents. It is not widely used today except in resistant cases.
Pharmacokinetic parameters reported in healthy adults after oral administration.