.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J04A_DrugsForTreatmentOfTuberculosis.J04AB01_Cycloserine.Cycloserine

Information

Cycloserine is an antibiotic primarily used for the treatment of tuberculosis, particularly for multidrug-resistant Mycobacterium tuberculosis. It is a broad-spectrum antibiotic and acts by inhibiting cell wall synthesis. It is still used today as a second-line treatment option in cases where first-line drugs are ineffective or contraindicated.

Pharmacokinetics

Pharmacokinetic parameters reported in adult healthy volunteers after oral administration.

References

1. Zhou, H, et al., & Wu, L (2015). Pharmacokinetic Properties and Tolerability of Cycloserine Following Oral Administration in Healthy Chinese Volunteers: A Randomized, Open-Label, Single- and Multiple-Dose 3-Way Crossover Study. Clinical therapeutics 37(6) 1292–1300. DOI:10.1016/j.clinthera.2015.03.015 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25869627

2. Zhu, M, et al., & Peloquin, CA (2001). Pharmacokinetics of cycloserine under fasting conditions and with high-fat meal, orange juice, and antacids. Pharmacotherapy 21(8) 891–897. DOI:10.1592/phco.21.11.891.34524 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11718495

3. Nix, DE, et al., & Peloquin, CA (2004). Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid. Tuberculosis (Edinburgh, Scotland) 84(6) 365–373. DOI:10.1016/j.tube.2004.04.001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15525560

Revisions

• 06/2025 initial generated model