.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J04A_DrugsForTreatmentOfTuberculosis.J04AB02_Rifampicin.Rifampicin

Information

name:Rifampicin
ATC code:J04AB02
route:oral
n-compartments2

Rifampicin is a broad-spectrum antibiotic used primarily for the treatment of tuberculosis and leprosy. It works by inhibiting bacterial DNA-dependent RNA polymerase and is a key component of first-line anti-tuberculosis therapy. Rifampicin is currently approved and widely used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters reported in adult healthy volunteers following single oral administration of rifampicin.

References

  1. Abulfathi, AA, et al., & Reuter, H (2019). Clinical Pharmacokinetics and Pharmacodynamics of Rifampicin in Human Tuberculosis. Clinical pharmacokinetics 58(9) 1103–1129. DOI:10.1007/s40262-019-00764-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31049868

  2. Abulfathi, AA, et al., & Svensson, EM (2021). The Population Pharmacokinetics of Meropenem in Adult Patients With Rifampicin-Sensitive Pulmonary Tuberculosis. Frontiers in pharmacology 12 637618–None. DOI:10.3389/fphar.2021.637618 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34267655

  3. Marsot, A, et al., & Blin, O (2017). Population pharmacokinetics of rifampicin in adult patients with osteoarticular infections: interaction with fusidic acid. British journal of clinical pharmacology 83(5) 1039–1047. DOI:10.1111/bcp.13178 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27813241

Revisions


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