.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J04A_DrugsForTreatmentOfTuberculosis.J04AK01_Pyrazinamide.Pyrazinamide

Information

name:Pyrazinamide
ATC code:J04AK01
route:oral
n-compartments1

Pyrazinamide is a synthetic pyrazine analogue antitubercular agent used primarily for the treatment of active tuberculosis as part of combination therapy. It is included in standard first-line regimens recommended by the World Health Organization (WHO). It is approved and widely used today.

Pharmacokinetics

Pharmacokinetics reported for healthy adult volunteers after single oral dose administration.

References

  1. Abulfathi, AA, et al., & Reuter, H (2019). Clinical Pharmacokinetics and Pharmacodynamics of Rifampicin in Human Tuberculosis. Clinical pharmacokinetics 58(9) 1103–1129. DOI:10.1007/s40262-019-00764-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31049868

  2. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

  3. Zvada, SP, et al., & Simonsson, US (2014). Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses. The Journal of antimicrobial chemotherapy 69(5) 1339–1349. DOI:10.1093/jac/dkt524 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24486870

Revisions


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