.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J04A_DrugsForTreatmentOfTuberculosis.J04AM07_RifampicinEthambutolAndI.RifampicinEthambutolAndI .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J04A_DrugsForTreatmentOfTuberculosis.J04AM07_RifampicinEthambutolAndI.RifampicinEthambutolAndI| name: | RifampicinEthambutolAndIsoniazid |
| ATC code: | J04AM07 | route: | oral |
| n-compartments | 1 |
A fixed-dose combination antibacterial therapy containing rifampicin, ethambutol, and isoniazid, primarily used for the treatment of tuberculosis (TB). This combination is approved and recommended by WHO for TB therapy to improve adherence and reduce development of drug resistance.
Pharmacokinetic parameters estimated from the literature on the individual drugs in adult TB patients, as no published pharmacokinetic model was found for the fixed-dose combination of all three drugs together.
Chen, C, et al., & Simonsson, US (2016). Population pharmacokinetics, optimised design and sample size determination for rifampicin, isoniazid, ethambutol and pyrazinamide in the mouse. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 93 319–333. DOI:10.1016/j.ejps.2016.07.017 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27473307
Denti, P, et al., & Andersen, AB (2015). Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania. PloS one 10(10) e0141002–None. DOI:10.1371/journal.pone.0141002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26501782
Langdon, G, et al., & Simonsson, US (2005). Population pharmacokinetics of rifapentine and its primary desacetyl metabolite in South African tuberculosis patients. Antimicrobial agents and chemotherapy 49(11) 4429–4436. DOI:10.1128/AAC.49.11.4429-4436.2005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16251279