.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J04B_DrugsForTreatmentOfLepra.J04BA02_Dapsone.Dapsone

Information

Dapsone is a synthetic sulfone antibiotic used primarily in the treatment of leprosy (Hansen's disease), dermatitis herpetiformis, and as prophylaxis against Pneumocystis jirovecii pneumonia. It has bacteriostatic activity against Mycobacterium leprae and is sometimes used off-label for other dermatological conditions. Dapsone is still approved and in use today, especially where leprosy remains endemic.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers, oral administration.

References

1. Mirochnick, M, et al., & Spector, SA (2001). Population pharmacokinetics of dapsone in children with human immunodeficiency virus infection. Clinical pharmacology and therapeutics 70(1) 24–32. DOI:10.1067/mcp.2001.115891 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11452241

2. Mirochnick, M, et al., & McNamara, J (1999). Pharmacokinetics of dapsone administered daily and weekly in human immunodeficiency virus-infected children. Antimicrobial agents and chemotherapy 43(11) 2586–2591. DOI:10.1128/AAC.43.11.2586 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10543733

3. Gatti, G, et al., & Bassetti, D (1995). Pharmacokinetics of dapsone in human immunodeficiency virus-infected children. Antimicrobial agents and chemotherapy 39(5) 1101–1106. DOI:10.1128/AAC.39.5.1101 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7625796

Revisions

• 06/2025 initial generated model