.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AB01_Aciclovir.Aciclovir

Information

Aciclovir (also known as acyclovir) is an antiviral drug used primarily for the treatment of infections caused by herpes simplex virus (HSV) and varicella-zoster virus (VZV), such as genital herpes, cold sores, shingles, and chickenpox. It inhibits viral DNA polymerase and is approved for clinical use worldwide.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after oral administration.

References

1. O'Brien, JJ, & Campoli-Richards, DM (1989). Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs 37(3) 233–309. DOI:10.2165/00003495-198937030-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2653790

2. Patel, R (1997). Valaciclovir: development, clinical utility and potential. Expert opinion on investigational drugs 6(2) 173–189. DOI:10.1517/13543784.6.2.173 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15989601

3. Noble, S, & Faulds, D (1998). Ganciclovir. An update of its use in the prevention of cytomegalovirus infection and disease in transplant recipients. Drugs 56(1) 115–146. DOI:10.2165/00003495-199856010-00012 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9664203

Revisions

• 06/2025 initial generated model