.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AB03_Vidarabine.Vidarabine .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AB03_Vidarabine.Vidarabine| name: | Vidarabine |
| ATC code: | J05AB03 | route: | intravenous |
| n-compartments | 2 |
Vidarabine (adenine arabinoside, Ara-A) is a purine nucleoside analogue antiviral that was historically used to treat herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections, including herpes encephalitis and herpes keratitis. Its use has declined due to the availability of safer and more effective antivirals like acyclovir; vidarabine is no longer commonly used or approved in current clinical practice.
Pharmacokinetics in adult patients after intravenous administration, primarily for herpes simplex treatment. Published data refer to adult populations without significant organ impairment.
Assouline, S, et al., & Badoux, X (2016). Pharmacokinetics, safety, and efficacy of subcutaneous versus intravenous rituximab plus chemotherapy as treatment for chronic lymphocytic leukaemia (SAWYER): a phase 1b, open-label, randomised controlled non-inferiority trial. The Lancet. Haematology 3(3) e128–e138. DOI:10.1016/S2352-3026(16)00004-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26947201
Ben Hassine, K, et al., & Ansari, M (2021). Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study. CPT: pharmacometrics & systems pharmacology 10(9) 1043–1056. DOI:10.1002/psp4.12683 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34453497
Podichetty, JT, et al., & Kiel, PJ (2020). Pharmacokinetics of Basiliximab for the Prevention of Graft-versus-Host Disease in Patients Undergoing Hematopoietic Cell Transplantation with Minimal-Intensity Cyclophosphamide and Fludarabine. Pharmacotherapy 40(1) 26–32. DOI:10.1002/phar.2347 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31742732