.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AB12_Cidofovir.Cidofovir .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AB12_Cidofovir.Cidofovir| name: | Cidofovir | |
| ATC code: | J05AB12 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 5 | mg |
| volume of distribution: | 8.8 | L |
| clearance: | 177 | ml/min |
| other parameters in model implementation | ||
Cidofovir is an acyclic nucleoside phosphonate antiviral medication, primarily used for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It is approved for intravenous use and is generally reserved for cases where other treatments have failed or are not tolerated, due to its potential nephrotoxicity and limited oral bioavailability.
Pharmacokinetic parameters reported in HIV-infected patients with cytomegalovirus retinitis after a single intravenous dose.
Marshall, BC, & Koch, WC (2009). Antivirals for cytomegalovirus infection in neonates and infants: focus on pharmacokinetics, formulations, dosing, and adverse events. Paediatric drugs 11(5) 309–321. DOI:10.2165/11316080-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19725597