.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AD01_Foscarnet.Foscarnet .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AD01_Foscarnet.Foscarnet| name: | Foscarnet | |
| ATC code: | J05AD01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 60 | mg |
| volume of distribution: | 0.32 | L |
| clearance: | 7.5 | mL/min/kg |
| other parameters in model implementation | ||
Foscarnet is an antiviral drug that acts as a pyrophosphate analog, inhibiting viral DNA polymerases and reverse transcriptases. It is mainly used for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS and for acyclovir-resistant herpes simplex virus (HSV) infections. Foscarnet is approved for medical use in the United States and other countries for these indications.
Pharmacokinetic parameters reported in adult HIV-positive patients with normal renal function after intravenous infusion.
Marshall, BC, & Koch, WC (2009). Antivirals for cytomegalovirus infection in neonates and infants: focus on pharmacokinetics, formulations, dosing, and adverse events. Paediatric drugs 11(5) 309–321. DOI:10.2165/11316080-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19725597