.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AF06_Abacavir.Abacavir

Information

name:Abacavir
ATC code:J05AF06
route:oral
n-compartments1

Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) used as part of antiretroviral therapy (ART) for the treatment of HIV-1 infection in adults and children. It is approved for use in combination with other antiretroviral agents.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects after oral administration.

References

  1. Zhao, W, et al., & Jacqz-Aigrain, E (2013). Population pharmacokinetics of abacavir in infants, toddlers and children. British journal of clinical pharmacology 75(6) 1525–1535. DOI:10.1111/bcp.12024 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23126277

  2. Zhao, W, et al., & Jacqz-Aigrain, E (2012). Population pharmacokinetics and maximum a posteriori probability Bayesian estimator of abacavir: application of individualized therapy in HIV-infected infants and toddlers. British journal of clinical pharmacology 73(4) 641–650. DOI:10.1111/j.1365-2125.2011.04121.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/21988586

  3. Singh, RP, et al., & Wynne, B (2021). Pharmacokinetics, Safety, and Tolerability of a Single Oral Dose of Abacavir/Dolutegravir/Lamivudine Combination Tablets in Healthy Japanese Study Participants. Clinical pharmacology in drug development 10(9) 985–993. DOI:10.1002/cpdd.996 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34265164

Revisions


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