.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AF09_Emtricitabine.Emtricitabine

Information

name:Emtricitabine
ATC code:J05AF09
route:oral
n-compartments1

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) used as an antiretroviral drug in the treatment and prevention of HIV-1 infection. It is often used in combination with other antiretrovirals and is approved for clinical use worldwide.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult individuals after oral administration of 200 mg emtricitabine.

References

  1. Valade, E, et al., & Hirt, D (2014). Population pharmacokinetics of emtricitabine in HIV-1-infected adult patients. Antimicrobial agents and chemotherapy 58(4) 2256–2261. DOI:10.1128/AAC.02058-13 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24492366

  2. Dickinson, L, et al., & Boffito, M (2020). Population pharmacokinetics and pharmacogenetics of ritonavir-boosted darunavir in the presence of raltegravir or tenofovir disoproxil fumarate/emtricitabine in HIV-infected adults and the relationship with virological response: a sub-study of the NEAT001/ANRS143 randomized trial. The Journal of antimicrobial chemotherapy 75(3) 628–639. DOI:10.1093/jac/dkz479 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31754703

  3. Néant, N, et al., & Solas, C (2018). Population pharmacokinetics of Rilpivirine in HIV-1-infected patients treated with the single-tablet regimen rilpivirine/tenofovir/emtricitabine. European journal of clinical pharmacology 74(4) 473–481. DOI:10.1007/s00228-017-2405-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29374296

Revisions


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