.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AG04_Etravirine.Etravirine .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AG04_Etravirine.Etravirine| name: | Etravirine |
| ATC code: | J05AG04 | route: | oral |
| n-compartments | 2 |
Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection. It is usually administered in combination with other antiretroviral agents and is approved for use in treatment-experienced adult and pediatric patients with HIV who have evidence of viral replication and HIV-1 strains resistant to other NNRTIs.
Pharmacokinetics in HIV-1-infected adult patients, population PK model after multiple oral dosing.
Kakuda, TN, et al., & Hoetelmans, RM (2010). Pharmacokinetics and pharmacodynamics of the non-nucleoside reverse-transcriptase inhibitor etravirine in treatment-experienced HIV-1-infected patients. Clinical pharmacology and therapeutics 88(5) 695–703. DOI:10.1038/clpt.2010.181 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20881958