.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AH02_Oseltamivir.Oseltamivir .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AH02_Oseltamivir.Oseltamivir| name: | Oseltamivir |
| ATC code: | J05AH02 | route: | oral |
| n-compartments | 1 |
Oseltamivir is an antiviral medication that inhibits influenza virus neuraminidase, thereby interfering with the release of progeny influenza virus from infected host cells. It is primarily used for the treatment and prophylaxis of influenza A and B. Oseltamivir is approved for clinical use and remains a standard therapy for seasonal influenza.
Pharmacokinetic parameters reported for healthy adult subjects (mixed sex, ages 18-65) after single oral dose administration of oseltamivir phosphate.
Davies, BE (2010). Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations. The Journal of antimicrobial chemotherapy 65 Suppl 2(Suppl 2) ii5–ii10. DOI:10.1093/jac/dkq015 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20215135
Rayner, CR, et al., & Jonsson, EN (2008). Population pharmacokinetics of oseltamivir when coadministered with probenecid. Journal of clinical pharmacology 48(8) 935–947. DOI:10.1177/0091270008320317 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18524996
Reddy, MB, et al., & Govorkova, EA (2015). Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design. PloS one 10(10) e0138069–None. DOI:10.1371/journal.pone.0138069 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26460484