.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AP10_Elbasvir.Elbasvir .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AP10_Elbasvir.Elbasvir| name: | Elbasvir |
| ATC code: | J05AP10 | route: | oral |
| n-compartments | 1 |
Elbasvir is an oral, direct-acting antiviral drug that acts as an inhibitor of the hepatitis C virus (HCV) NS5A protein, which is essential for viral replication. It is approved for use in combination with grazoprevir in the treatment of chronic HCV infection in adults. Elbasvir is currently used in clinical practice.
Pharmacokinetic parameters reported in healthy adult subjects after a single oral dose.
Marshall, WL, et al., & Yeh, WW (2018). Pharmacokinetics, Safety, and Tolerability of Single-Dose Elbasvir in Participants with Hepatic Impairment. European journal of drug metabolism and pharmacokinetics 43(3) 321–329. DOI:10.1007/s13318-017-0451-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29247332
Landaverde, C, et al., & Goldstein, JL (2016). Dual therapy of grazoprevir and elbasvir for the treatment of hepatitis C infection. Expert review of gastroenterology & hepatology 10(4) 419–429. DOI:10.1586/17474124.2016.1147346 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26818134
Roth, D, et al., & Greaves, W (2015). Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 study. Lancet (London, England) 386(10003) 1537–1545. DOI:10.1016/S0140-6736(15)00349-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26456905