.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AP11_Grazoprevir.Grazoprevir

Information

name:Grazoprevir
ATC code:J05AP11
route:oral
n-compartments2

Grazoprevir is an oral inhibitor of the hepatitis C virus (HCV) NS3/4A protease, approved for use in combination with elbasvir for the treatment of chronic HCV genotype 1 and 4 infections in adults. It is used as part of direct-acting antiviral regimens and is currently approved and used in clinical practice.

Pharmacokinetics

Pharmacokinetics in healthy adult subjects, oral administration of single 100 mg dose.

References

  1. Landaverde, C, et al., & Goldstein, JL (2016). Dual therapy of grazoprevir and elbasvir for the treatment of hepatitis C infection. Expert review of gastroenterology & hepatology 10(4) 419–429. DOI:10.1586/17474124.2016.1147346 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26818134

  2. Roth, D, et al., & Greaves, W (2015). Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 study. Lancet (London, England) 386(10003) 1537–1545. DOI:10.1016/S0140-6736(15)00349-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26456905

  3. Marshall, WL, et al., & Yeh, WW (2018). Pharmacokinetics, Safety, and Tolerability of Single-Dose Elbasvir in Participants with Hepatic Impairment. European journal of drug metabolism and pharmacokinetics 43(3) 321–329. DOI:10.1007/s13318-017-0451-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29247332

Revisions


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