.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J05A_DirectActingAntivirals.J05AR01_ZidovudineAndLamivudine.ZidovudineAndLamivudine

Information

name:ZidovudineAndLamivudine
ATC code:J05AR01
route:oral
n-compartments1

Zidovudine and lamivudine are antiretroviral medications combined to treat HIV-1 infection. Both are nucleoside reverse transcriptase inhibitors (NRTIs) and are used as a backbone in combination antiretroviral therapy (ART). The fixed-dose combination is approved and widely used today for the management of HIV infection.

Pharmacokinetics

Pharmacokinetic parameters for zidovudine and lamivudine following oral administration in healthy adult volunteers.

References

  1. Zhou, XJ, et al., & Sommadossi, JP (2000). Plasma population pharmacokinetics and penetration into cerebrospinal fluid of indinavir in combination with zidovudine and lamivudine in HIV-1-infected patients. AIDS (London, England) 14(18) 2869–2876. DOI:10.1097/00002030-200012220-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11153668

  2. Anderson, PL, et al., & Fletcher, CV (2006). Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. Journal of acquired immune deficiency syndromes (1999) 42(4) 441–449. DOI:10.1097/01.qai.0000225013.53568.69 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16791115

  3. Bhana, N, et al., & Figgitt, DP (2002). Zidovudine: a review of its use in the management of vertically-acquired pediatric HIV infection. Paediatric drugs 4(8) 515–553. DOI:10.2165/00128072-200204080-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12126455

Revisions


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