.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01A_AlkylatingAgents.L01AA06_Ifosfamide.Ifosfamide

Information

name:Ifosfamide
ATC code:L01AA06
route:intravenous
n-compartments2

Ifosfamide is an alkylating agent of the oxazaphosphorine group, used primarily as a chemotherapeutic agent for the treatment of various cancers including testicular cancer, sarcomas, and lymphomas. It is an FDA-approved cytotoxic drug commonly administered in combination with other chemotherapeutics.

Pharmacokinetics

Pharmacokinetic parameters reported in adult cancer patients (various types, both sexes), administered as intravenous infusion.

References

  1. Reif, S, et al., & Jaehde, U (2002). Population pharmacokinetics of etoposide. International journal of clinical pharmacology and therapeutics 40(12) 578–579. DOI:10.5414/cpp40578 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12503821

  2. Kerbusch, T, et al., & Beijnen, JH (2001). Population pharmacokinetics of ifosfamide and its 2- and 3-dechloroethylated and 4-hydroxylated metabolites in resistant small-cell lung cancer patients. Cancer chemotherapy and pharmacology 48(1) 53–61. DOI:10.1007/s002800100277 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11488525

  3. Kerbusch, T, et al., & Beijnen, JH (2001). Population pharmacokinetics and exploratory pharmacodynamics of ifosfamide and metabolites after a 72-h continuous infusion in patients with soft tissue sarcoma. European journal of clinical pharmacology 57(6-7) 467–477. DOI:10.1007/s002280100322 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11699611

Revisions


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