modelTreosulfan
Extends from Pharmacolibrary.Drugs.ATC.L.L01AB02.
Information
| name: | Treosulfan | |
| ATC code: | L01AB02 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 14 | mg |
| volume of distribution: | 24.8 | L |
| clearance: | 6.05 | L/h |
| other parameters in model implementation | ||
Treosulfan is an alkylating agent used in conditioning regimens prior to hematopoietic stem cell transplantation (HSCT), mainly for treatment of hematological malignancies and some non-malignant diseases. It is currently approved and in clinical use in several countries for both adults and children as a part of preparative regimens for transplantation.
Pharmacokinetics
Pharmacokinetic parameters reported in adult patients undergoing allogeneic stem cell transplantation receiving intravenous treosulfan. Mean values from population PK analyses.
References
Rosser, SPA, et al., & Nath, CE (2023). Evaluation of treosulfan cumulative exposure in paediatric patients through population pharmacokinetics and dosing simulations. British journal of clinical pharmacology 89(4) 1413–1424. DOI:10.1111/bcp.15599 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36369677
Danielak, D, et al., & Główka, F (2018). Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation. European journal of clinical pharmacology 74(1) 79–89. DOI:10.1007/s00228-017-2344-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/28975382
Li, X, et al., & Sykora, KW (2023). Population pharmacokinetic modeling of treosulfan and rationale for dose recommendation in children treated for conditioning prior to allogeneic hematopoietic stem cell transplantation. Drug metabolism and pharmacokinetics 52 100515–None. DOI:10.1016/j.dmpk.2023.100515 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37481830
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)