name: | Treosulfan |
ATC code: | L01AB02 | route: | intravenous |
n-compartments | 2 |
Treosulfan is an alkylating agent used in conditioning regimens prior to hematopoietic stem cell transplantation (HSCT), mainly for treatment of hematological malignancies and some non-malignant diseases. It is currently approved and in clinical use in several countries for both adults and children as a part of preparative regimens for transplantation.
Pharmacokinetic parameters reported in adult patients undergoing allogeneic stem cell transplantation receiving intravenous treosulfan. Mean values from population PK analyses.
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Danielak, D, et al., & Główka, F (2018). Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation. European journal of clinical pharmacology 74(1) 79–89. DOI:10.1007/s00228-017-2344-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/28975382
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