.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01A_AlkylatingAgents.L01AB02_Treosulfan.Treosulfan

Information

name:Treosulfan
ATC code:L01AB02
route:intravenous
n-compartments2

Treosulfan is an alkylating agent used in conditioning regimens prior to hematopoietic stem cell transplantation (HSCT), mainly for treatment of hematological malignancies and some non-malignant diseases. It is currently approved and in clinical use in several countries for both adults and children as a part of preparative regimens for transplantation.

Pharmacokinetics

Pharmacokinetic parameters reported in adult patients undergoing allogeneic stem cell transplantation receiving intravenous treosulfan. Mean values from population PK analyses.

References

  1. Rosser, SPA, et al., & Nath, CE (2023). Evaluation of treosulfan cumulative exposure in paediatric patients through population pharmacokinetics and dosing simulations. British journal of clinical pharmacology 89(4) 1413–1424. DOI:10.1111/bcp.15599 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36369677

  2. Danielak, D, et al., & Główka, F (2018). Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation. European journal of clinical pharmacology 74(1) 79–89. DOI:10.1007/s00228-017-2344-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/28975382

  3. Li, X, et al., & Sykora, KW (2023). Population pharmacokinetic modeling of treosulfan and rationale for dose recommendation in children treated for conditioning prior to allogeneic hematopoietic stem cell transplantation. Drug metabolism and pharmacokinetics 52 100515–None. DOI:10.1016/j.dmpk.2023.100515 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37481830

Revisions


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