.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01A_AlkylatingAgents.L01AX03_Temozolomide.Temozolomide

Information

name:Temozolomide
ATC code:L01AX03
route:oral
n-compartments1

Temozolomide is an oral alkylating agent, primarily used in the treatment of certain brain tumors such as glioblastoma multiforme and anaplastic astrocytoma. It is approved for use in many countries and is considered a standard of care for high-grade gliomas.

Pharmacokinetics

Pharmacokinetic parameters reported for adult cancer patients (glioblastoma), mixed sexes, typical age range 18-70 years, normal renal and hepatic function.

References

  1. Singh, R, et al., & Beumer, JH (2019). Population pharmacokinetics and exposure-response assessment of veliparib co-administered with temozolomide in patients with myeloid leukemias. Cancer chemotherapy and pharmacology 83(2) 319–328. DOI:10.1007/s00280-018-3731-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30456480

  2. Büsker, S, et al., & Peyrl, A (2022). Pharmacokinetics of metronomic temozolomide in cerebrospinal fluid of children with malignant central nervous system tumors. Cancer chemotherapy and pharmacology 89(5) 617–627. DOI:10.1007/s00280-022-04424-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35355137

  3. Panetta, JC, et al., & Stewart, CF (2003). Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors. Cancer chemotherapy and pharmacology 52(6) 435–441. DOI:10.1007/s00280-003-0670-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/13680158

Revisions


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