modelTegafur_1
Extends from Pharmacolibrary.Drugs.ATC.L.L01BC03_1.
Information
| name: | Tegafur_1 | |
| ATC code: | L01BC03_1 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 250 | mg |
| volume of distribution: | 25 | L |
| clearance: | 5.2 | L/h |
| other parameters in model implementation | ||
Tegafur is an anticancer prodrug of 5-fluorouracil (5-FU), typically used in combination with other agents such as uracil or gimeracil/oteracil (as UFT or S-1 formulations) for the oral treatment of various solid tumors, including gastrointestinal cancers. While tegafur is not widely used as monotherapy today, its combinational forms remain approved and in clinical use, primarily in Asia.
Pharmacokinetics
Pharmacokinetic parameters obtained in cancer patients after intravenous bolus dose, assessed using a two-compartment model.
References
Sugiyama, E, et al., & Sawada, J (2010). Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms. Clinical pharmacokinetics 49(8) 549–558. DOI:10.2165/11532970-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20608756
Blum, M, et al., & Ajani, JA (2011). A comprehensive review of S-1 in the treatment of advanced gastric adenocarcinoma. Future oncology (London, England) 7(6) 715–726. DOI:10.2217/fon.11.50 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21675835
Urien, S, et al., & Deporte-Fety, R (2003). Modelling of ftorafur and 5-fluorouracil pharmacokinetics following oral UFT administration. A population study in 30 patients with advanced breast cancer. Cancer chemotherapy and pharmacology 52(2) 99–107. DOI:10.1007/s00280-003-0616-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12768319
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)