modelCapecitabine
Extends from Pharmacolibrary.Drugs.ATC.L.L01BC06.
Information
| name: | Capecitabine | |
| ATC code: | L01BC06 | route: | oral |
| compartments: | 1 | |
| dosage: | 2000 | mg |
| volume of distribution: | 186 | L |
| clearance: | 585 | mL/min |
| other parameters in model implementation | ||
Capecitabine is an oral prodrug of 5-fluorouracil (5-FU), used as a chemotherapy agent primarily for the treatment of metastatic breast cancer and colorectal cancer. It is approved and widely used in clinical oncology. The drug is enzymatically converted to 5-FU preferentially in tumor tissues.
Pharmacokinetics
Pharmacokinetics of capecitabine in adult cancer patients (median age ~56 years, both sexes, solid tumors), following repeated oral administration of 1250 mg/m2 twice daily for 14 days in a 21-day cycle.
References
Jacobs, BAW, et al., & Huitema, ADR (2019). Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis. CPT: pharmacometrics & systems pharmacology 8(12) 940–950. DOI:10.1002/psp4.12474 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31652031
Janssen, JM, et al., & Dorlo, TPC (2021). Population Pharmacokinetics of Intracellular 5-Fluorouridine 5'-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine. The AAPS journal 23(1) 23–None. DOI:10.1208/s12248-020-00533-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33417061
Li, X, et al., & Zheng, L (2023). Pharmacokinetics and Comparative Bioavailability of Test or Reference Capecitabine and Discrepant Pharmacokinetics Among Various Tumors in Chinese Solid Cancer Patients. Clinical pharmacology in drug development 12(3) 324–332. DOI:10.1002/cpdd.1202 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36642942
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)