.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01C_PlantAlkaloidsAndOtherNaturalProducts.L01CA03_Vindesine.Vindesine

Information

Vindesine is a semi-synthetic vinca alkaloid chemotherapeutic agent, structurally related to vincristine and vinblastine. It disrupts microtubule formation, inhibiting mitosis in cancer cells. Vindesine has been used primarily in the treatment of various malignancies, including acute lymphoblastic leukemia, malignant melanoma, breast cancer, and lung cancer. While it has seen global use since its introduction, vindesine is now less commonly used and is not approved in certain countries, such as the United States.

Pharmacokinetics

PK parameters reported in adult cancer patients receiving intravenous vindesine, from non-compartmental and compartmental pharmacokinetic studies.

References

1. Zhu, RH, et al., & Peng, WX (2014). Validated HILIC-MS/MS assay for determination of vindesine in human plasma: Application to a population pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 96 31–36. DOI:10.1016/j.jpba.2014.03.017 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24721203

2. Tran, L, et al., & Huitema, AD (2010). Pharmacokinetics of rituximab in patients with CD20 positive B-cell malignancies. Human antibodies 19(1) 7–13. DOI:10.3233/HAB-2010-0215 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20555126

Revisions

• 06/2025 initial generated model