.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01C_PlantAlkaloidsAndOtherNaturalProducts.L01CA04_Vinorelbine.Vinorelbine_1 .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01C_PlantAlkaloidsAndOtherNaturalProducts.L01CA04_Vinorelbine.Vinorelbine_1| name: | Vinorelbine_1 | |
| ATC code: | L01CA04_1 | route: | oral |
| compartments: | 2 | |
| dosage: | 60 | mg |
| volume of distribution: | 5.7 | L |
| clearance: | 0.47 | L/h/kg |
| other parameters in model implementation | ||
Vinorelbine is a semi-synthetic vinca alkaloid antineoplastic agent primarily used for treatment of non-small cell lung cancer and metastatic breast cancer.
Oral vinorelbine pharmacokinetics in adult cancer patients; values based on clinical studies with oral administration. Bioavailability is less than intravenous.
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Hamimed, M, et al., & Leblond, P (2022). Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low-grade glioma. British journal of clinical pharmacology 88(5) 2096–2117. DOI:10.1111/bcp.15131 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34709655
Hamimed, M, et al., & Ciccolini, J (2022). Impact of pharmacogenetics on variability in exposure to oral vinorelbine among pediatric patients: a model-based population pharmacokinetic analysis. Cancer chemotherapy and pharmacology 90(1) 29–44. DOI:10.1007/s00280-022-04446-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/35751658