.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01C_PlantAlkaloidsAndOtherNaturalProducts.L01CE02_Irinotecan.Irinotecan .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01C_PlantAlkaloidsAndOtherNaturalProducts.L01CE02_Irinotecan.Irinotecan| name: | Irinotecan |
| ATC code: | L01CE02 | route: | intravenous |
| n-compartments | 2 |
Irinotecan is a semisynthetic derivative of camptothecin and acts as a topoisomerase I inhibitor. It is primarily used as a chemotherapeutic agent for the treatment of colorectal cancer, among other solid tumors. Irinotecan is approved for use in multiple countries for metastatic colorectal cancer, often in combination with other agents (e.g., 5-fluorouracil and leucovorin).
Population pharmacokinetic parameters for total irinotecan in adult patients with solid tumors, following intravenous infusion.
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