.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01C_PlantAlkaloidsAndOtherNaturalProducts.L01CX01_Trabectedin.Trabectedin .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01C_PlantAlkaloidsAndOtherNaturalProducts.L01CX01_Trabectedin.Trabectedin| name: | Trabectedin |
| ATC code: | L01CX01 | route: | intravenous |
| n-compartments | 3 |
Trabectedin is an antineoplastic agent originally derived from the sea squirt Ecteinascidia turbinata and now produced synthetically. It binds to the minor groove of DNA, disrupting the cell cycle and leading to apoptosis. Trabectedin is approved for the treatment of soft tissue sarcomas and relapsed ovarian cancer, often in patients who have failed previous chemotherapy.
Population pharmacokinetics in adult cancer patients (including both sexes), typically receiving trabectedin via intravenous infusion as a single agent.
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Perez-Ruixo, JJ, et al., & Owen, JS (2007). Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients. Clinical pharmacokinetics 46(10) 867–884. DOI:10.2165/00003088-200746100-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17854236
Zelek, L, et al., & Misset, JL (2006). A phase II study of Yondelis (trabectedin, ET-743) as a 24-h continuous intravenous infusion in pretreated advanced breast cancer. British journal of cancer 94(11) 1610–1614. DOI:10.1038/sj.bjc.6603142 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16736024