modelDaunorubicin
Extends from Pharmacolibrary.Drugs.ATC.L.L01DB02.
Information
| name: | Daunorubicin | |
| ATC code: | L01DB02 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 60 | mg |
| volume of distribution: | 1.1 | L |
| clearance: | 37 | ml/min/m2 |
| other parameters in model implementation | ||
Daunorubicin is an anthracycline antibiotic antineoplastic agent used primarily in the treatment of acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL). It works by intercalating DNA and inhibiting topoisomerase II, leading to inhibition of DNA replication and repair. The drug is approved and used today, mostly in combination chemotherapy protocols for leukemia.
Pharmacokinetics
Pharmacokinetic parameters reported in adult patients with acute myeloid leukemia after intravenous infusion of daunorubicin.
References
Hempel, G, et al., & Boos, J (2003). Population pharmacokinetics of liposomal daunorubicin in children. British journal of clinical pharmacology 56(4) 370–377. DOI:10.1046/j.1365-2125.2003.01886.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12968981
Pefani, E, et al., & Pistikopoulos, EN (2014). Chemotherapy drug scheduling for the induction treatment of patients with acute myeloid leukemia. IEEE transactions on bio-medical engineering 61(7) 2049–2056. DOI:10.1109/TBME.2014.2313226 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24686224
Douer, D, et al., & Avramis, VI (2007). Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia. Blood 109(7) 2744–2750. DOI:10.1182/blood-2006-07-035006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17132721
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)