.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01D_CytotoxicAntibioticsAndRelatedSubstances.L01DB03_Epirubicin.Epirubicin

Information

Epirubicin is an anthracycline antineoplastic agent used primarily in the treatment of breast cancer. It works as a DNA synthesis inhibitor, intercalating into DNA and inhibiting topoisomerase II. Epirubicin is approved for use in multiple countries for the treatment of breast cancer and is sometimes used in other solid tumors as part of combination chemotherapy regimens.

Pharmacokinetics

Adult cancer patients, both sexes, typical intravenous administration as part of chemotherapy, based on population PK analyses.

References

1. Ismael, G, et al., & Jackisch, C (2012). Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): a phase 3, open-label, multicentre, randomised trial. The Lancet. Oncology 13(9) 869–878. DOI:10.1016/S1470-2045(12)70329-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22884505

2. Prado, CM, et al., & Sawyer, MB (2011). An exploratory study of body composition as a determinant of epirubicin pharmacokinetics and toxicity. Cancer chemotherapy and pharmacology 67(1) 93–101. DOI:10.1007/s00280-010-1288-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/20204364

3. Müller, HJ, et al., & Mross, K (2002). The influence of elevated liver function parameters on the pharmacokinetics of doxorubicin and epirubicin--a population based pharmacokinetic study of CESAR-APOH. Central European Society for Anticancer Drug Research. Working Group for Pharmacology in Oncology and Hematology. International journal of clinical pharmacology and therapeutics 40(12) 575–577. DOI:10.5414/cpp40575 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12503820

Revisions

• 06/2025 initial generated model