.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01E_ProteinKinaseInhibitors.L01EK02_Cediranib.Cediranib .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01E_ProteinKinaseInhibitors.L01EK02_Cediranib.Cediranib| name: | Cediranib |
| ATC code: | L01EK02 | route: | oral |
| n-compartments | 1 |
Cediranib is an orally available small-molecule tyrosine kinase inhibitor that selectively inhibits vascular endothelial growth factor (VEGF) receptors. It was developed primarily for its anti-angiogenic properties, targeting tumor blood vessel growth in various cancers. Cediranib has been investigated in clinical trials for malignancies such as ovarian, lung, and colorectal cancers, but as of 2024, it is not approved for routine clinical use by major regulatory agencies.
Pharmacokinetic parameters in adult cancer patients (various solid tumors) after single and multiple oral doses of cediranib.
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Li, J, et al., & Masson, E (2017). Population pharmacokinetic and exposure simulation analysis for cediranib (AZD2171) in pooled Phase I/II studies in patients with cancer. British journal of clinical pharmacology 83(8) 1723–1733. DOI:10.1111/bcp.13266 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28213941
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