.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01E_ProteinKinaseInhibitors.L01EX02_Sorafenib.Sorafenib .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01E_ProteinKinaseInhibitors.L01EX02_Sorafenib.Sorafenib| name: | Sorafenib | |
| ATC code: | L01EX02 | route: | oral |
| compartments: | 2 | |
| dosage: | 400 | mg |
| volume of distribution: | 71 | L |
| clearance: | 8.8 | L/h |
| other parameters in model implementation | ||
Sorafenib is a multikinase inhibitor approved for the treatment of advanced renal cell carcinoma, unresectable hepatocellular carcinoma, and differentiated thyroid carcinoma. It acts by inhibiting tumor cell proliferation and angiogenesis.
Pharmacokinetic parameters reported in adult cancer patients (solid tumors), both male and female, after multiple oral doses.
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