.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01E_ProteinKinaseInhibitors.L01EX08_Lenvatinib.Lenvatinib

Information

name:Lenvatinib
ATC code:L01EX08
route:oral
n-compartments2

Lenvatinib is a multi-kinase inhibitor indicated for the treatment of certain types of cancer, including differentiated thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma. It is an oral anticancer drug currently approved for use in several regions including the US and EU.

Pharmacokinetics

Population pharmacokinetic analysis in patients with advanced solid tumors, administered orally, typical adult population.

References

  1. Hu, Y, et al., & Zeng, Y (2022). Population Pharmacokinetic Modeling of Lenvatinib in Chinese Patients With Advanced Hepatocellular Carcinoma Using Real-World Data. Journal of clinical pharmacology 62(12) 1507–1517. DOI:10.1002/jcph.2103 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35689595

  2. Wei, Y, et al., & Zhang, X (2023). Effects of diet and gender on the pharmacokinetics of oral lenvatinib: A clinical trial in healthy Chinese participants. International journal of clinical pharmacology and therapeutics 61(11) 475–481. DOI:10.5414/CP204440 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37644876

  3. Gupta, A, et al., & Hussein, Z (2016). Population pharmacokinetic analysis of lenvatinib in healthy subjects and patients with cancer. British journal of clinical pharmacology 81(6) 1124–1133. DOI:10.1111/bcp.12907 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26879594

Revisions


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