.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01E_ProteinKinaseInhibitors.L01EX11_Quizartinib.Quizartinib_1 .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01E_ProteinKinaseInhibitors.L01EX11_Quizartinib.Quizartinib_1| name: | Quizartinib_1 |
| ATC code: | L01EX11_1 | route: | oral |
| n-compartments | 1 |
Quizartinib is an oral, selective type II FLT3 inhibitor used in the treatment of acute myeloid leukemia (AML) with FLT3-ITD mutations. It is approved for use in adult patients and has demonstrated efficacy in relapsed or refractory AML.
Single-dose administration to healthy volunteers; parameters from noncompartmental analysis.
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Usuki, K, et al., & Sakajiri, S (2019). Safety and pharmacokinetics of quizartinib in Japanese patients with relapsed or refractory acute myeloid leukemia in a phase 1 study. International journal of hematology 110(6) 654–664. DOI:10.1007/s12185-019-02709-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31359361