modelPembrolizumab
Extends from Pharmacolibrary.Drugs.ATC.L.L01FF02.
Information
| name: | Pembrolizumab | |
| ATC code: | L01FF02 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 200 | mg |
| volume of distribution: | 6.0 | L |
| clearance: | 0.2 | L/day |
| other parameters in model implementation | ||
Pembrolizumab is a humanized monoclonal antibody that blocks the interaction between PD-1, a receptor on T cells, and its ligands, PD-L1 and PD-L2, thereby promoting immune-mediated anti-tumor activity. It is primarily used in the treatment of various cancers, including melanoma, non-small cell lung cancer, head and neck squamous cell carcinoma, classical Hodgkin lymphoma, and others. Pembrolizumab is FDA-approved for multiple cancer indications and is in active clinical use.
Pharmacokinetics
Pharmacokinetic parameters reported for adult cancer patients (both sexes, broad adult age range) receiving intravenous pembrolizumab monotherapy.
References
Freshwater, T, et al., & Stone, JA (2017). Evaluation of dosing strategy for pembrolizumab for oncology indications. Journal for immunotherapy of cancer 5 43–None. DOI:10.1186/s40425-017-0242-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28515943
Lala, M, et al., & Jain, L (2020). A six-weekly dosing schedule for pembrolizumab in patients with cancer based on evaluation using modelling and simulation. European journal of cancer (Oxford, England : 1990) 131 68–75. DOI:10.1016/j.ejca.2020.02.016 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32305010
Baranda, JC, et al., & Hodi, FS (2024). Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of SAR439459, a TGFβ inhibitor, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors: Findings from a phase 1/1b study. Clinical and translational science 17(6) e13854–None. DOI:10.1111/cts.13854 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38898592
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)